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The George Brown Botanic Gardens have significance as the site of major botanical and agricultural activity since 1886, for their association with the Holtze and Agostini families and with the former Lord Mayor of Darwin, George Brown. Maurice Holtze was appointed Government Gardener in 1878 and successfully curated the ‘Experimental Nursery’ and gardens first at a site near the Gaol at Fannie Bay and, after 1886, at the current site. Nicholas Holtze took over from his father in 1892 when Maurice became curator of the Adelaide Botanic Gardens.